Pharmacology
Anti inflammatory drugs
Question # 1 (Multiple Answer) Manifestations of rheumatoid arthritis:
A) inflammatory synovitis B) cartilage destruction C) bone erosion D) changes in joint integrity E) progressive, relentless polyarthritis with functional impairment
Question # 2 (Multiple Choice) The major role in chronic management of arthritis:
A) glucocorticoids B) nonsteroidal antiinflammatory drugs
Question # 3 (Multiple Choice) Mechanism of action: aspirin-platelet effects:
A) promotes platelet aggregation B) activates thromboxane synthesis C) both D) neither
Question # 4 (Multiple Answer) Factors accounting for rheumatoid arthritis incidence:
A) genetics B) climate C) urbanization
Question # 5 (Multiple Choice) Mediator most likely to promote pain:
A) histamine B) serotonin C) bradykinin D) prostaglandins E) leukotrienes
Question # 6 (True/False) Aspirin: bleeding time
A) increases bleeding time B) decreases bleeding time
Question # 7 (True/False) Genetic risk factors fully account for the incidence of rheumatoid arthritis.
A) true B) false
Question # 8 (Multiple Choice) At low doses required to inhibition of thymidylate synthase, an enhanced adenosine release
A) chloroquine B) gold C) methotrexate D) cyclophosphamide to E) ketorolac
Question # 9 (Multiple Choice) Mediator promoting greatest increase in vascular permeability, associated with acute inflammation:
A) serotonin B) prostaglandins C) bradykinin D) leukotrienes
Question # 10 (Multiple Choice) Isozyme primarily responsible for prostaglandin production by cells involve an inflammation:
A) COX-I B) COX-II
Question # 11 (Multiple Answer) Aspirin and antipyresis:
A) elevation of body temperature is typically a useful defense mechanism
B) aspirin -- best available drug for reducing fever (in the absence of contraindications to its use recurrent
C) aspirin -- more effective in lowering elevated temperature than normal body temperature
D) aspirin-induced temperature reduction is caused by vasodilation
E) fever associated with infection: caused by actions of prostaglandins and interleukin 1 at the periphery
Question # 12 (Multiple Answer) Phases of inflammation:
A) acute inflammation B) the immune response C) chronic inflammation
Question # 13 (Multiple Answer) Advantages of other NSAIDs compared with aspirin:
A) generally less expensive B) less gastric irritation C) potentially better compliance (e.g. naproxen, sulindac) D) easier to establish therapeutic range using blood levels E) absence of acute renal failure/nephrotic syndrome
Question # 14 (Multiple Answer) Aspirin:
A) inhibits prostaglandin synthase B) inhibits cyclooxygenase C) decreases prostaglandin formation D) decreases thromboxane A2 formation E) decreases leukotrienes
Question # 15 (Multiple Answer) Mediators of chronic inflammation in rheumatoid arthritis:
A) IL-1 B) IL-2 C) IL-3 D) TNF alpha E) interferons
Question # 16 (Multiple Choice) Effective in managing acute gouty arthritisand ankylosing spondylitis; also accelerates closure of patent ductus arteriosus in premature infants:
A) gold B) ketorolac C) phenylbutazone D) methotrexate E) indomethacin
Question # 17 (Multiple Choice) Approximate prevalence of rheumatoid arthritis:
A) 1% B) 5% C) 7% D) 10% E) 15%
Question # 18 (Multiple Choice) In rheumatoid arthritis: primary effect of this mediator is on prostaglandin production:
A) PDGF (platelet-derived growth factor) B) GM-CSF C) TNF alpha
Question # 19 (Multiple Choice) Analgesic effects of aspirin:
A) peripheral action (inflammation) B) subcortical site of action C) both D) neither
Question # 20 (True/False) rheumatoid arthritis: genetic predisposition
A) yes B) no
Question # 21 (Multiple Answer) Correct drug-drug interactions:
A) aspirin -- acetazolamide: enhanced salicylate intoxication B) aspirin -- spironolactone: reduced spironolactone activity C) aspirin -- probenecid: increased uricosuric activity D) aspirin -- phenytoin: increased free phenytoin serum levels E) aspirin-alcohol: increased gastrointestinal bleeding
Question # 22 (Multiple Choice) NSAID primarily promoted as an analgesic, not as an anti-inflammatory agent:
A) piroxicam B) ibuprofen C) naproxen D) ketorolac E) sulindac
Question # 23 (Multiple Choice) Drug associated with the hepatic/renal toxic metabolite: N-acetyl-p-benzoquinone
A) diclofenac B) meclofenamate C) indomethacin D) acetaminophen E) aspirin
Correct answers
Question # 1 (Multiple Answer) Manifestations of rheumatoid arthritis:
(A) inflammatory synovitis
(B) cartilage destruction
(C) bone erosion
(D) changes in joint integrity
(E) progressive, relentless polyarthritis with functional impairment
Question # 2 (Multiple Choice) The major role in chronic management of arthritis:
Answer: (B) nonsteroidal antiinflammatory drugs
Question # 3 (Multiple Choice) Mechanism of action: aspirin-platelet effects:
Answer: (D) neither
Question # 4 (Multiple Answer) Factors accounting for rheumatoid arthritis incidence:
(A) genetics
(B) climate
(C) urbanization
Question # 5 (Multiple Choice) Mediator most likely to promote pain:
Answer: (C) bradykinin
Question # 6 (True/False) Aspirin: bleeding time
Answer: True
Question # 7 (True/False) Genetic risk factors fully account for the incidence of rheumatoid arthritis.
Answer: False
Question # 8 (Multiple Choice) At low doses required to inhibition of thymidylate synthase, an enhanced adenosine release
Answer: (C) methotrexate
Question # 9 (Multiple Choice) Mediator promoting greatest increase in vascular permeability, associated with acute inflammation:
Answer: (D) leukotrienes
Question # 10 (Multiple Choice) Isozyme primarily responsible for prostaglandin production by cells involve an inflammation:
Answer: (B) COX-II
Question # 11 (Multiple Answer) Aspirin and antipyresis:
(B) aspirin -- best available drug for reducing fever (in the absence of contraindications to its use recurrent
(C) aspirin -- more effective in lowering elevated temperature than normal body temperature
(D) aspirin-induced temperature reduction is caused by vasodilation
Question # 12 (Multiple Answer) Phases of inflammation:
(A) acute inflammation
(B) the immune response
(C) chronic inflammation
Question # 13 (Multiple Answer) Advantages of other NSAIDs compared with aspirin:
(B) less gastric irritation
(C) potentially better compliance (e.g. naproxen, sulindac)
Question # 14 (Multiple Answer) Aspirin:
(A) inhibits prostaglandin synthase
(B) inhibits cyclooxygenase
(C) decreases prostaglandin formation
(D) decreases thromboxane A2 formation
Question # 15 (Multiple Answer) Mediators of chronic inflammation in rheumatoid arthritis:
(A) IL-1
(B) IL-2
(C) IL-3
(D) TNF alpha
(E) interferons
Question # 16 (Multiple Choice) Effective in managing acute gouty arthritisand ankylosing spondylitis; also accelerates closure of patent ductus arteriosus in premature infants:
Answer: (E) indomethacin
Question # 17 (Multiple Choice) Approximate prevalence of rheumatoid arthritis:
Answer: (A) 1%
Question # 18 (Multiple Choice) In rheumatoid arthritis: primary effect of this mediator is on prostaglandin production:
Answer: (C) TNF alpha
Question # 19 (Multiple Choice) Analgesic effects of aspirin:
Answer: (C) both
Question # 20 (True/False) rheumatoid arthritis: genetic predisposition
Answer: True
Question # 21 (Multiple Answer) Correct drug-drug interactions:
(A) aspirin -- acetazolamide: enhanced salicylate intoxication
(B) aspirin -- spironolactone: reduced spironolactone activity
(D) aspirin -- phenytoin: increased free phenytoin serum levels
Question # 22 (Multiple Choice) NSAID primarily promoted as an analgesic, not as an anti-inflammatory agent:
Answer: (D) ketorolac
Question # 23 (Multiple Choice) Drug associated with the hepatic/renal toxic metabolite: N-acetyl-p-benzoquinone
Answer: (D) acetaminophen
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