Pharmacology 1
Pharmacodynamics
Question # 1 (Multiple Answer) Concerning drug receptor interactions, the constant Kd refers to:
A) maximal physiological effect B) maximal binding C) the drug concentration required to occupy 50% of receptors D) drug concentration that results in half-maximal physiological response E) all of the above
Question # 2 (Multiple Answer) Signal transduction involves G protein coupled receptor systems:
A) biogenic amines B) peptide hormones C) eicosanoids
Question # 3 (Multiple Choice) Example(s) of second messenger effect(s):
A) increases in cAMP intracellular concentration B) changes in intracellular calcium concentration C) phosphoinositide effects D) all the above
Question # 4 (Multiple Choice) EC50 mainly reflexs a drug's:
A) maximal effect B) potency C) lethality D) ease of elimination E) safety
Question # 5 (Multiple Answer) Physiological processes mediated by the intracellular second messenger, cyclic AMP:
A) carbohydrate breakdown by the liver B) decreased heart rate C) increased contractility D) smooth muscle relaxation E) triglyceride breakdown
Question # 6 (True/False) Drug effects are thought to be proportional to the number of occupied receptors
A) true B) false
Question # 7 (Multiple Choice) Nitric oxide mediates this effect on vascular smooth muscle:
A) smooth muscle relaxation B) smooth muscle contraction C) no effect
Question # 8 (Multiple Choice) Receptors are usually:
A) lipids B) proteins C) DNA
Question # 9 (Multiple Choice) Longer-lasting physiological response to drug:
A) increase in heart rate following epinephrine infusion B) changes in gene product production following corticosteroid injection.
Question # 10 (Multiple Answer) True statement(s) concerning competitive inhibition:
A) competitive in addition is based on reversible drug/antagonist binding at receptor sites B) with competitive inhibition, the dose-effects curve the shifted to the left C) with competitive inhibition, maximal drug effect cannot be obtained, even at high agonist concentrations D) all the above
Question # 11 (Multiple Answer) Example(s) of endogenous ligands that interact with membrane-integrated ion channels and affect(s) ion conductance.
A) acetylcholine B) GABA C) glutamate D) aspartate E) glycine
Question # 12 (Multiple Answer) Example(s) of (a) receptor(s) which is/are enzyme(s):
A) dihydrofolate reductase B) acetylcholinesterase C) monoamine oxidase
Question # 13 (Multiple Choice) Primary mechanism by which cAMP effects are terminated:
A) enzyme-catalyzed dephosphorylation B) reuptake into presynaptic nerve terminals
Question # 14 (Multiple Choice) An example of a receptor which is a structural protein.
A) Na/K ATPase B) acetylcholinesterase C) tubulin D) DNA E) phospholipase C
Question # 15 (Multiple Choice) An example of an agent that exerts much of its effects through intracellular receptors that in complex form binds to DNA response elements:
A) acetylcholine B) dopamine C) corticosteroids D) diltiazem E) atropine
Question # 16 (Multiple Choice) Factors that may cause variation in drug responsiveness:
A) changes in the number or function of receptors B) tachyphylaxis C) idiosyncratic drug responses D) hypersensitivity reactions E) all of the above
Question # 17 (Multiple Answer) Major roles of receptors:
A) determine rate of drug elimination B) determine drug action selectivity C) provide a means of blocking drug action as well as mediating drug action D) act as drug storage sites
Answers
Question # 1 (Multiple Answer) Concerning drug receptor interactions, the constant Kd refers to:
(C) the drug concentration required to occupy 50% of receptors
(D) drug concentration that results in half-maximal physiological response
Question # 2 (Multiple Answer) Signal transduction involves G protein coupled receptor systems:
(A) biogenic amines
(B) peptide hormones
(C) eicosanoids
Question # 3 (Multiple Choice) Example(s) of second messenger effect(s):
Answer: (D) all the above
Question # 4 (Multiple Choice) EC50 mainly reflexs a drug's:
Answer: (B) potency
Question # 5 (Multiple Answer) Physiological processes mediated by the intracellular second messenger, cyclic AMP:
(A) carbohydrate breakdown by the liver
(C) increased contractility
(D) smooth muscle relaxation
(E) triglyceride breakdown
Question # 6 (True/False) Drug effects are thought to be proportional to the number of occupied receptors
Answer: True
Question # 7 (Multiple Choice) Nitric oxide mediates this effect on vascular smooth muscle:
Answer: (A) smooth muscle relaxation
Question # 8 (Multiple Choice) Receptors are usually:
Answer: (B) proteins
most commonly proteins; DNA may serve as a receptor for certain agents-- such as certain anticancer drugs.
Question # 9 (Multiple Choice) Longer-lasting physiological response to drug:
Answer: (B) changes in gene product production following corticosteroid injection.
Question # 10 (Multiple Answer) True statement(s) concerning competitive inhibition:
(A) competitive in addition is based on reversible drug/antagonist binding at receptor sites
Question # 11 (Multiple Answer) Example(s) of endogenous ligands that interact with membrane-integrated ion channels and affect(s) ion conductance.
(A) acetylcholine
(B) GABA
(C) glutamate
(D) aspartate
(E) glycine
Question # 12 (Multiple Answer) Example(s) of (a) receptor(s) which is/are enzyme(s):
(A) dihydrofolate reductase
(B) acetylcholinesterase
(C) monoamine oxidase
Question # 13 (Multiple Choice) Primary mechanism by which cAMP effects are terminated:
Answer: (A) enzyme-catalyzed dephosphorylation
Question # 14 (Multiple Choice) An example of a receptor which is a structural protein.
Answer: (C) tubulin
Question # 15 (Multiple Choice) An example of an agent that exerts much of its effects through intracellular receptors that in complex form binds to DNA response elements:
Answer: (C) corticosteroids
Question # 16 (Multiple Choice) Factors that may cause variation in drug responsiveness:
Answer: (E) all of the above
Question # 17 (Multiple Answer) Major roles of receptors:
(B) determine drug action selectivity
(C) provide a means of blocking drug action as well as mediating drug action
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