Pharmacology 9
Gonadal pharmacology
Question # 1 (Multiple Answer) Progesterone pharmacokinetics:
A) slow absorption B) limited hepatic metabolism C) conjugated with glucuronic acid following metabolism to pregnanediol D) all of the above
Question # 2 (Multiple Answer) Risk factors for osteoporosis:
A) Caucasian B) thin C) excessive physical activity D) smoking E) family history
Question # 3 (Multiple Choice) Major secretory product of the ovary:
A) estrone B) estriol C) estradiol D) androstenedione E) progesterone
Question # 4 (Multiple Choice) In the circulation,estradiol binds mainly to:
A) alpha-2 globulin B) albumin C) both equally D) binds to neither
Question # 5 (Multiple Choice) Most important progestin in humans:
A) megestrol acetate B) Medroxyprogesterone acetate C) progesterone D) L-Norgestrel E) desogestrel
Question # 6 (Multiple Answer) Adverse effects associated with estrogen use:
A) postmenopausal bleeding B) nausea C) hyperpigmentation D) cholestasis E) hypertension
Question # 7 (Multiple Answer) Estrogen effects:
A) increase progesterone receptor synthesis B) affect human libido C) produce edema D) affect sympathetic nervous system control of smooth muscle function E) increase plasma volume
Question # 8 (Multiple Choice) Estrogen-induced increases in uterine blood flow,
A) requires gene activation B) results from interaction with intracellular receptors C) is probably mediated by membrane receptors
Question # 9 (Multiple Answer) Progesterone:
A) estrogen precursor B) androgen precursor C) adrenocortical steroids precursor D) synthesized in the ovary mainly by the corpus luteum E) synthesized in the adrenal from circulating cholesterol
Question # 10 (Multiple Choice) The high ratio of liver to peripheral actions of estrogens is probably due to :
A) binding to specific liver proteins B) enterohepatic circulation C) the predominance of estrogen receptors located in the liver
Question # 11 (Multiple Answer) Estrogen effectsr blood coagulation:
A) decreased factor II B) increased factor VII C) decreased antithrombin III D) decreased factor IX E) decreased factor X
Question # 12 (Multiple Answer) Lipid changes following menopause or oophorectomy:
A) increased plasma cholesterol B) increased LDL C) decreased LDL receptor number D) HDL -- minor effects
Question # 13 (Multiple Choice) Continuous, prolonged exposure of the endometrium estrogen causes:
A) abnormal endometrial hyperplasia B) abnormal bleeding patterns C) both D) neither
Question # 14 (Multiple Choice) Used to treat primary hypogonadism:
A) conjugated estrogen B) ethinyl estradiol C) both D) neither
Question # 15 (Multiple Answer) Commonly used estrogens
A) micronized estradiol B) quinestrol C) androstenedione D) estradiol cypionate E) ethinyl estradiol
Question # 16 (Multiple Answer) Metabolic estrogen effects:
A) decreased plasma triglyceride B) increased circulating thyroxine C) increased circulating testosterone D) decreased high-density lipoproteins E) increased renin substrate
Question # 17 (Multiple Choice) Most estrone and estriol are formed from estradiol in this organ:
A) ovary B) liver C) adrenal D) lung E) kidney
Question # 18 (Multiple Choice) Estrogen uses:
A) suppression of ovulation in patients with intractable dysmenorrhea (combined with progestins) B) treatment of hirsuitism/amenorrhea due to excessive androgen secretion C) stop excessive uterine bleeding due to endometrial hyperplasia D) all of the above
Question # 19 (Multiple Choice) Causes of estrogen deficiencies:
A) castration B) menopause C) ovarian development failure D) all of the above
Question # 20 (Multiple Choice) Examples of synthetic,nonsteroidal estrogens:
A) dienestrol B) diethylstilbestrol C) chlorotrianisene D) methallenestril E) all of the above
Question # 21 (Multiple Choice) Onset of ovarian function may be due to maturation of brain centers that withdraw an inhibition of cells in the hypothalamus allow them to produce:
A) FSH B) L. H. C) GnRH D) AST E) TBG
Question # 22 (Multiple Choice) During the first part of the menstrual cycle, before ovulation, estrogens are produced in the ovarian follicle by:
A) theca cells B) granulosa cells of the corpus luteum C) both D) neither
Question # 23 (Multiple Choice) Major non-human source of estrogenic substances:
A) porcine (pig) B) stallion C) chicken D) cow E) swordfishin
Answers
Question # 1 (Multiple Answer) Progesterone pharmacokinetics:
(C) conjugated with glucuronic acid following metabolism to pregnanediol
Question # 2 (Multiple Answer) Risk factors for osteoporosis:
(A) Caucasian
(B) thin
(D) smoking
(E) family history
Question # 3 (Multiple Choice) Major secretory product of the ovary:
Answer: (C) estradiol
Question # 4 (Multiple Choice) In the circulation,estradiol binds mainly to:
Answer: (A) alpha-2 globulin
Question # 5 (Multiple Choice) Most important progestin in humans:
Answer: (C) progesterone
Question # 6 (Multiple Answer) Adverse effects associated with estrogen use:
(A) postmenopausal bleeding
(B) nausea
(C) hyperpigmentation
(D) cholestasis
(E) hypertension
Question # 7 (Multiple Answer) Estrogen effects:
(A) increase progesterone receptor synthesis
(B) affect human libido
(C) produce edema
(D) affect sympathetic nervous system control of smooth muscle function
Question # 8 (Multiple Choice) Estrogen-induced increases in uterine blood flow,
Answer: (C) is probably mediated by membrane receptors
Question # 9 (Multiple Answer) Progesterone:
(A) estrogen precursor
(B) androgen precursor
(C) adrenocortical steroids precursor
(D) synthesized in the ovary mainly by the corpus luteum
(E) synthesized in the adrenal from circulating cholesterol
Question # 10 (Multiple Choice) The high ratio of liver to peripheral actions of estrogens is probably due to :
Answer: (B) enterohepatic circulation
Question # 11 (Multiple Answer) Estrogen effectsr blood coagulation:
(B) increased factor VII
(C) decreased antithrombin III
Question # 12 (Multiple Answer) Lipid changes following menopause or oophorectomy:
(A) increased plasma cholesterol
(B) increased LDL
(C) decreased LDL receptor number
(D) HDL -- minor effects
Question # 13 (Multiple Choice) Continuous, prolonged exposure of the endometrium estrogen causes:
Answer: (C) both
Question # 14 (Multiple Choice) Used to treat primary hypogonadism:
Answer: (C) both
Question # 15 (Multiple Answer) Commonly used estrogens
(A) micronized estradiol
(B) quinestrol
(D) estradiol cypionate
(E) ethinyl estradiol
Question # 16 (Multiple Answer) Metabolic estrogen effects:
(B) increased circulating thyroxine
(C) increased circulating testosterone
(E) increased renin substrate
Question # 17 (Multiple Choice) Most estrone and estriol are formed from estradiol in this organ:
Answer: (B) liver
Question # 18 (Multiple Choice) Estrogen uses:
Answer: (D) all of the above
Question # 19 (Multiple Choice) Causes of estrogen deficiencies:
Answer: (D) all of the above
Question # 20 (Multiple Choice) Examples of synthetic,nonsteroidal estrogens:
Answer: (E) all of the above
Question # 21 (Multiple Choice) Onset of ovarian function may be due to maturation of brain centers that withdraw an inhibition of cells in the hypothalamus allow them to produce:
Answer: (C) GnRH
Question # 22 (Multiple Choice) During the first part of the menstrual cycle, before ovulation, estrogens are produced in the ovarian follicle by:
Answer: (C) both
Question # 23 (Multiple Choice) Major non-human source of estrogenic substances:
Answer: (B) stallion
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