Pharmacology 2
Autacoids
Question # 1 (Multiple Answer) CNS serotonin:
A) mood B) sleep C) appetite D) pain perception E) vomiting
Question # 2 (True/False) Propofol (Diprivan) for induction and maintenance of anesthesia may be as effective as ondansetron (Zofran) in reducing/preventing postoperative emesis
A) true B) false
Question # 3 (Multiple Choice) Serotonin overproduction (carcinoid tumor):
A) constipation B) diarrhea
Question # 4 (Multiple Choice) Major clinical use(s): cyproheptadine (Periactin):
A) reduces smooth muscle effects of carcinoid tumor B) reduces postgastrectomy dumping syndrome C) both D) neither
Question # 5 (Multiple Choice) Widely distributed indoleethylamine formed from tryptophan:
A) epinephrine B) nicotine C) serotonin D) leukotriene E) prostaglandins
Question # 6 (True/False) Serotonin -- gastrointestinal tract effects:decreased peristalsis
A) true B) false
Question # 7 (Multiple Choice) Antiemetic agent with least side effects
A) chlorpromazine (Thorazine) B) butyrophenones C) ondansetron (Zofran) D) diphenhydramine (Benadryl)
Question # 8 (Multiple Choice) Serotonin: platelet effects --
A) promotes aggregation B) inhibits aggregation
Question # 9 (Multiple Choice) Greater than 90% of serotonin is located here:
A) platelets B) raphe nucleus (brain stem) C) enterochromaffin cells of the GI tract D) lung E) cerebral cortex
Question # 10 (Multiple Answer) Cardiovascular effects of serotonin:
A) skeletal muscle vasculature: vasodilatation B) reflex bradycardia C) pulmonary and renal vasculature: vasoconstriction
Question # 11 (Multiple Answer) Sumatriptan (Imitrex) and migraine:
A) relieves symptoms for few patients B) efficacy greater than or equal to other drug treatments C) multiple dosing may be required
Question # 12 (Multiple Answer) Serotonin agonists -- clinical use:
A) buspirone -- anxiolytic B) sumatriptan (Imitrex) -- antimigraine; anti-cluster headaches C) both D) neither
Question # 13 (Multiple Answer) Serotonin: nervous system --
A) stimulates itch and pain sensory nerve endings B) activates chemosensitive nerve endings in coronary vessels C) atropine-sensitive bradycardia D) activates medullary vomiting reflex (5 HT3)
Question # 14 (Multiple Choice) ondansetron (Zofran), granisetron (Kytril), tropisetron interact with its serotonin receptor subtype located in the area postrema, sensory, and enteric nerves:
A) 5 HT1a B) 5 HT1d C) 5 HT3 D) 5 HT4
Question # 15 (Multiple Choice) Sumatriptan (Imitrex) -- contraindications
A) presence of ischemic heart disease B) patients have variant (Prinzmetal's) angina C) both D) neither
Question # 16 (Multiple Answer) Ondansetron (Zofran) -- pharmacology:
A) activates dopamine (Intropin), histamine and adrenergic receptors B) very effective for prevention of nausea iand vomiting caused by chemotherapy or surgery C) reduces postoperative vomiting in patients following middle ear surgery
Question # 17 (Multiple Answer) Adverse effects -- sumatriptan (Imitrex)
A) muscle weakness B) chest pain C) dizziness D) altered sensations (tingling, warmth recurrent
Answers
Question # 1 (Multiple Answer) CNS serotonin:
(A) mood
(B) sleep
(C) appetite
(D) pain perception
(E) vomiting
Question # 2 (True/False) Propofol (Diprivan) for induction and maintenance of anesthesia may be as effective as ondansetron (Zofran) in reducing/preventing postoperative emesis
Answer: True
Question # 3 (Multiple Choice) Serotonin overproduction (carcinoid tumor):
Answer: (B) diarrhea
Question # 4 (Multiple Choice) Major clinical use(s): cyproheptadine (Periactin):
Answer: (C) both
Question # 5 (Multiple Choice) Widely distributed indoleethylamine formed from tryptophan:
Answer: (C) serotonin
Question # 6 (True/False) Serotonin -- gastrointestinal tract effects:decreased peristalsis
Answer: False
Question # 7 (Multiple Choice) Antiemetic agent with least side effects
Answer: (C) ondansetron (Zofran)
Question # 8 (Multiple Choice) Serotonin: platelet effects --
Answer: (A) promotes aggregation
Question # 9 (Multiple Choice) Greater than 90% of serotonin is located here:
Answer: (C) enterochromaffin cells of the GI tract
Question # 10 (Multiple Answer) Cardiovascular effects of serotonin:
(A) skeletal muscle vasculature: vasodilatation
(B) reflex bradycardia
(C) pulmonary and renal vasculature: vasoconstriction
Question # 11 (Multiple Answer) Sumatriptan (Imitrex) and migraine:
(B) efficacy greater than or equal to other drug treatments
(C) multiple dosing may be required
Question # 12 (Multiple Answer) Serotonin agonists -- clinical use:
(C) both
Question # 13 (Multiple Answer) Serotonin: nervous system --
(A) stimulates itch and pain sensory nerve endings
(B) activates chemosensitive nerve endings in coronary vessels
(C) atropine-sensitive bradycardia
(D) activates medullary vomiting reflex (5 HT3)
Question # 14 (Multiple Choice) ondansetron (Zofran), granisetron (Kytril), tropisetron interact with its serotonin receptor subtype located in the area postrema, sensory, and enteric nerves:
Answer: (C) 5 HT3
Question # 15 (Multiple Choice) Sumatriptan (Imitrex) -- contraindications
Answer: (C) both
Question # 16 (Multiple Answer) Ondansetron (Zofran) -- pharmacology:
(B) very effective for prevention of nausea iand vomiting caused by chemotherapy or surgery
(C) reduces postoperative vomiting in patients following middle ear surgery
Question # 17 (Multiple Answer) Adverse effects -- sumatriptan (Imitrex)
(A) muscle weakness
(B) chest pain
(C) dizziness
(D) altered sensations (tingling, warmth recurrent
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